interfaces to date have been in large part limited to electrical
modalities for both recording and stimulation. The integration of
microfluidics with microelectrode technology is being explored to
create hybrid neural interfaces that enable spatial and temporal
control of both electrical and chemical inputs/outputs to culture
cells and tissue.
The objective of this
proposal is to develop novel biocompatible
microsystems for achieving seamless interfaces
between engineered devices and biological systems.
Biological systems communicate via exchange of both
electrical and chemical signals.
Microelectromechanical systems (MEMS) consisting of
integrated microelectrodes and microfluidics will be
developed that mimic cellular communication at
biological spatial and temporal scales. These
integrated systems allow multi-channel
bi-directional electrochemical interaction with
cells and tissue at a level of sophistication not
possible with existing instrumentation. Devices will
incorporate polymer construction to address
biofouling and bioreactivity.
(funding source: NSF CAREER award)
(funding source: NSF BMES ERC)